Understanding Recurrent Miscarriages

• Definition: Recurrent Miscarriages (RM) or Recurrent Pregnancy Losses (RPL) are defined as having two or more consecutive pregnancy losses before 20 weeks of gestation by Royal Australian and New Zealand College of Obstetricians and Gynaecologists (RANZCOG)
• Prevalence: According to RANZCOG, approximately 1% - 4% of couples experience recurrent miscarriages, affecting both physical and emotional well-being.
• Emotional Impact: We understand that repeated pregnancy loss can lead to stress, anxiety, and uncertainty, making early guidance and support essential.
   

• Genetic Factors: Chromosomal abnormalities in embryos can be a significant contributor.
• Uterine Issues: Structural problems like fibroids, septum, or scar tissue may interfere with implantation.
• Hormonal Imbalances: Thyroid disorders or luteal phase defects can increase miscarriage risk.
• Immune and Blood Disorders: Conditions such as antiphospholipid syndrome can affect pregnancy maintenance.
• Lifestyle Factors: Smoking, excessive alcohol, obesity, and uncontrolled stress can also play a role.

• Women Over 35: Maternal age increases the likelihood of chromosomal abnormalities.
• Couples With Previous Miscarriages: Risk of recurrence is higher after two or more pregnancy losses.
• Individuals With Underlying Health Conditions: Thyroid disorders, diabetes, or clotting disorders require careful monitoring.

• After Two Miscarriages: It is recommended to consult a fertility specialist after two consecutive losses.
• During Preconception Planning: Early fertility assessment can help identify risks and improve pregnancy outcomes.

• Comprehensive Fertility Assessment: Blood tests, hormonal tests, and uterine imaging.
• Genetic Counselling: Identify potential chromosomal issues in both partners.
• Lifestyle Optimisation: Balanced diet, regular exercise, and stress management.
• Advanced Testing Techniques: Combine IVF treatment with PGT-A 

Preimplantation Genetic Testing for Aneuploidy (PGT-A):

• Helps identify embryos with chromosomal abnormalities before transfer.
• Increases the likelihood of a healthy pregnancy, reducing the emotional burden of repeated miscarriages.

PGT-A is usually for:

• Women over 35 years old
• Couples with multiple IVF failures
• Couples with recurrent miscarriages
• Couples who want to reduce the risk of having a baby with chromosome abnormality such as Down’s Syndrome

Want to know about PGT-A? Click here to learn more.

 Question #1: Can PGT-A guarantee a successful pregnancy?

• While PGT-A cannot guarantee pregnancy, it significantly reduces the risk of miscarriage due to chromosomal abnormalities, improving the chance of a healthy birth.

Question #2: Is recurrent miscarriage only a female issue?

• No. Male genetic factors and sperm quality can also contribute, making assessment of both partners essential.

Question #3: How long does the PGT-A process take?

• At Sunfert, PGT-A can be done within 2-3 weeks.

Question #4: Is PGT-A suitable for everyone?

• PGT-A is usually recommended for couples with recurrent miscarriage, advanced maternal age, previous IVF failures or want to reduce the risk of having a baby with chromosome abnormality such as Down’s Syndrome.