Pre-implantation Genetic Testing for Aneuploidies (PGT-A)

At Sunfert, we offer Pre-implantation Genetic Testing for Aneuploidies (PGT-A) as a genetic screening tool to examine embryos created through IVF before they are transferred to the uterus.

PGT-A helps us identify whether an embryo has the correct number of chromosomes. Chromosomes carry genetic information, and a healthy embryo typically contains 46 chromosomes arranged in 23 pairs.

To perform PGT-A accurately, we use a technology called Next-Generation Sequencing (NGS) at Sunfert. This is a top-notch advanced genetic testing technology in the industry that allows us to examine the DNA of an embryo in detail, helping us determine whether it has the correct number of chromosomes.

During the PGT-A process, a few cells are carefully taken from the embryo and analysed using NGS. This technology can screen all 23 pairs of chromosomes at once with high precision, allowing us to identify embryos that are chromosomally normal as well as those with chromosomal abnormalities. By selecting embryos with the correct chromosomal count, PGT-A helps improve the chances of successful implantation, supports a healthier pregnancy, and reduces the risk of miscarriage for patients undergoing IVF.

A normal embryo has 23 pairs of chromosomes. Chromosomal abnormalities occur when there is an extra chromosome, a missing chromosome, or a structural imbalance in the embryo. These abnormalities may increase the risk of:

• Implantation failure
• Miscarriage
• Genetic disorders

By screening embryos before transfer, we aim to select embryos with the correct chromosomal count to improve the chance of establishing a healthy pregnancy.

Some disorders that arise from chromosomal abnormalities include:

• Down’s Syndrome (Trisomy 21): caused by extra copy of chromosome 21
• Edwards’ Syndrome (Trisomy 18): caused by extra copy of chromosome 18
• Patau’s Syndrome (Trisomy 13): caused by extra copy of chromosome 13
• Turner Syndrome (Monosomy X): caused by a missing copy of chromosome X in female embryos
• Other numerical chromosomal abnormalities (aneuploidies) may lead to implantation failure or miscarriage

When combining IVF treatment with PGT-A, we can reduce the risk of transferring embryos with detectable chromosomal abnormalities.

We generally recommend PGT-A for individuals or couples who:

• are at an advanced maternal age
• have had recurrent miscarriages
• have experienced recurrent implantation failure
• have previously had a pregnancy affected by chromosomal abnormalities
• produce multiple embryos and want to prioritise chromosomally normal embryos
• wish to reduce the risk of transferring embryos affected by disorders such as Down’s Syndrome

At Sunfert, we assess each case individually to determine whether PGT-A is clinically appropriate for our patients’ fertility journey.

Our data and research at Sunfert shows that PGT-A benefits women of all age groups, especially those with advanced maternal age. As age increases, the number of transferable embryos decreases, and PGT-A can help identify the healthiest embryos for a higher chance of success.

The chart below is based on data from 4,497 blastocysts biopsied at Sunfert Group. The findings show that transferable embryo rates were highest among women below 35 years old, reaching up to 80%, while the transferable embryo rate among women aged 42 years old and above was approximately 10%.

PGT-A can benefit patients who want greater confidence in embryo selection before transfer.

We often see positive value for those who:

• are planning pregnancy at a later reproductive age
• want to minimise miscarriage risk linked to chromosomal abnormalities
• aim to increase the IVF treatment success rate with a more targeted, evidence-based embryo transfer plan.

For many patients, it provides reassurance by giving us additional genetic insight into the quality of their embryos.

Based on data collected from our patients, incorporating Pre-Implantation Genetic Testing (PGT) into IVF treatment improved IVF success rates and outcomes, including higher clinical pregnancy rates and implantation rates.

The comparison below shows the differences in clinical pregnancy and implantation rates between patients who underwent IVF with PGT and those who underwent IVF without PGT.

Sunfert Clinical Pregnancy Rate

Sunfert Clinical Implantation Rate

Notes:

• The Sunfert Clinical Pregnancy Rate and Implantation Rate (success rate) shown above were calculated based on data collected at Sunfert Bangsar South in 2024.
• In patients below 35, PGT is less frequently indicated. As a result, outcomes in this group are based on a smaller sample size, which may affect the observed clinical pregnancy rate.

Click here to learn more about Sunfert IVF Success Rate.

Step 1: IVF Treatment & Embryo Development

We stimulate the ovaries, retrieve the eggs, and fertilise them in our laboratory through IVF/ICSI.
The embryos are cultured until they reach the blastocyst stage (Day 5 or Day 6).

Step 2: Embryo Biopsy

Performed by our highly-trained embryologists or genetic scientists, a tiny cluster of cells is collected from the outer layer of the blastocyst (trophectoderm biopsy).

Step 3: Pre-implantation Genetic Testing for Aneuploidies

The biopsied cells undergo chromosomal testing using advanced genetic technology to determine if the embryo has the correct number of chromosomes.

The results are generated and shared with our patients and fertility specialists within 2 to 3 weeks.

Step 4: Embryo Selection and Transfer

Embryos identified as chromosomally normal (euploid) are prioritised for transfer in a subsequent cycle to improve the likelihood of a healthy pregnancy. 

Mosaic embryos, which contain a mix of normal and abnormal cells, may be considered for transfer in selected cases following careful clinical evaluation and counselling.

If you are facing fertility challenges, start with a consultation at Sunfert. We will guide you through your fertility journey with expertise and compassionate care. 

Make an appointment with our Fertility Specialist today and take the next step toward your parenthood goals.